SYNE1 and amyotrophic lateral sclerosis: Mutations within SYNE1 are currently linked to more diseases than SYNE2, these include; autosomal recessive cerebellar ataxia type 1 (ARCA1; OMIM #610743) [38,39], ataxia with amyotrophic lateral sclerosis (ALS)-like presentations [40,41], arthrogryposis multiplex congenita-3 (OMIM #618484) [42,43], Emery Dreifuss muscular dystrophy type 4 (OMIM #612998) [18,44] and dilated cardiomyopathy [45,46].