No statistically significant differences were found when evaluating WNT7B rs6519955, SFRP4 rs17171229 and RSPO2 rs611744 gene variants and daily physical labor, previously sustained hand injuries (traumatic injuries and surgeries, excluding surgical treatment of DC), DC stages, and the severity of DC diathesis (bilateral involvement, positive family history, <50 years of age on the onset of DC, male gender) [7]. This evidence concerns the gene RSPO2 and dyskeratosis congenita.