Single-nucleotide polymorphisms WNT7B rs6519955 and RSPO2 rs611744 are associated with the development of Dupuytren’s contracture: WNT7B rs6519955 genotype TT increases the chances by 3.5-fold and RSPO2 rs611744 genotype GG appears to attenuate the likelihood of the manifestation of DC nearly twofold. The gene discussed is RSPO2; the disease is Dupuytren Contracture.