Binary logistic regression analysis revealed that WNT7B rs6519955 genotype TT increased the chances of developing Dupuytren’s contracture by 3.5-fold (OR = 3.516; CI = 1.624–7.610; p = 0.001), whereas the RSPO2 rs611744 genotype GG appeared to attenuate the likelihood of the manifestation of DC nearly twofold (OR = 0.484, CI = 0.258–0.908, p = 0.024) (Table 3). Here, RSPO2 is linked to dyskeratosis congenita.