Consistent with this, another SNP in the AKT1 gene, rs2494732, which is in high linkage disequilibrium with rs1130233 (r2 = 0.45, D′ = 0.94), entails a variant—allele A—which has been shown to increase the risk of developing psychosis among cannabis users [72] and to interact with genetic variation in the DRD2 gene in further increasing the risk of psychosis possibly because of genetically-determined higher striatal dopamine levels [73]. This evidence concerns the gene DRD2 and psychotic disorder.