Although it is difficult to recapitulate the pathology of hyperphosphorylated tau, which contributes to the formation of neurofibrillary tangles in APP-transgenic AD mice, a close link between Aβ accumulation and tau pathology has been reported in induced pluripotent stem cell-derived neurons and three dimensional (3D) organoids of AD [1,2]. This evidence concerns the gene APP and Alzheimer disease.