Aberrant phase separation leading to the pathological amyloid fibrillation of fused in sarcoma (FUS), TAR DNA-binding protein 43 (TDP-43), tau, and α-synuclein (α-Syn} are now associated with neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer’s disease (AD), and Parkinson’s disorder (PD) [26,27,28,29]. Here, MAPT is linked to Alzheimer disease.