An analysis of datasets from the Cancer Genome Atlas Research Network (TCGA) acute myeloid leukemia (AML) study revealed that mutations and/or copy number variations in genes that write, read, or erase m6A methylations, such as METTL3, METTL14, YTHDF1, YTHDF2, FTO, and ALKBH5, are significantly correlated with p53 mutations in AML patients [1009]. The gene discussed is YTHDF1; the disease is acute myeloid leukemia.