The SUMOylation of METTL3 was found to promote tumor growth and colony formation in human non-small cell lung carcinoma (NSCLC) cells (H1299) [1039], where the SUMO1 modification of METTL3 at lysine residues K177, K211, K212, and K215 dramatically repressed methylation that decreased mRNA m6A levels in vitro and in vivo—a process that can be reduced by deSUMOylation enzyme sentrin/SUMO-specific protease 1 (SENP1) [1039,1040]. The gene discussed is SUMO1; the disease is neoplasm.