Fat mass and obesity-associated (FTO) protein, the m6A “eraser” associated with human obesity and energy homeostasis [976,977,978,979], was found to be upregulated in breast cancer [980], hepatocellular carcinoma [981], melanoma [982], and acute myeloid leukemia (AML) [983]; however, the downregulation of FTO in vivo and in vitro enhanced invasion and metastasis in epithelial cancers [984]. Here, FTO is linked to acute myeloid leukemia.