Melatonin inhibited NLRP3 inflammasome activation and reduced the aggregation of ASC specks in the mice hippocampus with major depressive disorder induced by inflammatory liposaccharides [312]; melatonin also inhibited the formation of hypoxia-induced inflammasome protein complexes and reduced the aggregation of ASC specks in macrophages of Sugen/hypoxia pulmonary arterial hypertension (PAH) mouse models [313]. Here, NLRP3 is linked to pulmonary arterial hypertension.