However, if knocking down ZFP217 (reduction in ATP by 25% in prostate cancer cells [1053]) and/or using doxycycline (~80% reduction in ATP in hypoxic stem-like prostate cancer cells [1054]) lowered ATP production in ESCs used in the experiment [1050], then it is possible that even in the presence of melatonin, the lack of ATP led to the failure of DDX3, an ATP-dependent helicase that regulates m6A mRNA methylation. The gene discussed is WRN; the disease is Familial prostate cancer.