The fact that degenerative diseases have been associated with IDR-containing pathological aggregates of p53, tau, TDP-43, and FUS [554,555,556,557], which are also important transcription factors [519,520,521,523] associated with SGs, emphasizes the relevance in the interactions between these MLOs for the dynamic assembly of SGs under stress conditions inhibiting the initiation of mRNA translations, and the necessity of their timely, rapid disassembly upon stress removal [558]. Here, TARDBP is linked to neurodegenerative disease.