YTHDF2 and lung carcinoma: However, in lung cancer, the SUMOylation of m6A “reader” YTHDF2 by SUMO1 at lysine residue K571 in vitro and in vivo increased the binding affinity of YTHDF2 to m6A-modified mRNAs, altering gene expression profiles, resulting in the increased proliferation, migration, colony formation and tumor growth of lung cancer H1299 cells [1042].