TP53 and cancer: More than 50% of all human cancers have been associated with missense [758] and/or synonymous mutations of the p53 gene [742,759,760,761], where close to 95% of these mutations are located in the DNA-binding domain (DBD) [12,742,762,763,764,765] which is regulated by interactions with the extensive intrinsically disordered regions of the C- and N-termini that flank the DBD [547,766,767,768].