However, overactivated microglia provide excessive amounts of the inflammatory ligands IL-6, IL-1β, and TNF-α, causing ROS, iNOS, NFκB, and NLRP3 inflammatory complex activation; additionally, disruption of neuronal homeostasis was observed in ischemic optic neuropathy [11,51,52]. The gene discussed is IL1B; the disease is anterior ischemic optic neuropathy.