NFE2L2 and type 2 diabetes mellitus: Finally, sulforaphane, an isothiocyanate present in broccoli, has shown to induce Nrf2-HO-1/NQO-1 signaling pathway [177], and its effect has been eva-luated in several diseases, such as Type 2 diabetes (NCT02801448, phase II) or metastatic breast cancer (NCT02970682, phase II).