EGCG mediated apoptosis induction in sarcoma cells was by the cell cycle arrest at G2/M phase, suppression of Bcl-2 and myc, expression of p53 and Bax, whereas the expression of other important targets of apoptosis such as p21, p27, Bcl-xL, mdm2, and cyclin D1 remains unchanged in sarcoma cells [147]. The gene discussed is MDM2; the disease is sarcoma.