The experiments distinguished the endogenous and the reconstituted MAS activity and were performed at three different stages of the cardiac damage: (1) early phase before 24 h (in our protocol, 3 h and 6 h after ISO administration); (2) myocardial infarction (at 24 h); (3) remodeling phase following the infarcted crisis (in our protocol, 48 h and 96 h after ISO administration). Here, MAS1 is linked to myocardial infarction.