NANOG and embryonal carcinoma: Although activation of the JAK/STAT/Nanog pathway by vitamin C and SVCT2 was initially associated with cellular pluripotency induction [16], a recent analysis in embryonal carcinoma F9 cells showed that SVCT2 functions as a receptor-like transporter of vitamin C, through the physical interaction between SVCT2 and JAK and the consequent activation of kinase in response to vitamin C [17].