It has been reported that pretreatment with EGCG (10, 20, and 30 mg/kg for 21 days) to ISO-induced MI in rats significantly increased the activities of SOD, CAT, GPx, GRx, and glutathione-S-transferase (GST) in the heart tissue, while the activities of these enzymes were declined significantly in the ISO-induced hearts, and these enzymatic changes were associated with reduced lipid peroxidation and cardioprotection manifested by improved heart ultrastructure [113]. The gene discussed is SOD1; the disease is myocardial infarction.