CYP2E1 and serum lipopolysaccharide activity: Furthermore, treatment with an antioxidant N-acetylcysteine or a selective inhibitor of CYP2E1 chlormethiazole (CMZ) suppressed the levels of intestinal CYP2E1 and alcohol-mediated endotoxemia [14,23], suggesting the important role of intestinal CYP2E1 and oxidative stress in promoting gut leakiness and inflammatory liver injury.