In addition, many natural products, such as indole-3-carbinol [34], diallyl sulfide [42], phenethyl isothiocyanate [43], resveratrol [44,45], berberine [46], melatonin [47], lycopene [48], ellagic acid [49], silibinin [50], silymarin [51], gallic acid [51], walnut phytochemicals [52], etc., can suppress CYP2E1 activity and thus, fatty liver disease. The gene discussed is CYP2E1; the disease is fatty liver disease.