The protective effects of pomegranate extract were also observed in both T84 human colon cancer cells and AML12 mouse hepatocytes after these cells were incubated with EA, which significantly attenuated the changes in the levels of gut CYP2E1, TJ/AJ proteins, and epithelial barrier dysfunction following ethanol exposure [13]. This evidence concerns the gene CYP2E1 and colonic neoplasm.