OPA1 and ischemia: With regard to cerebral ischemia/reperfusion, 8 min of global ischemia with 4–24 h of reperfusion increased OPA1 release in the brain of Sprague-Dawley rats [25], whereas 15 min of global ischemia with 1–72 h of reperfusion in Wistar rats decreased the expression and translocation of Mfn2 in cortical mitochondria but not in hippocampal mitochondria [35].