DNM1L and nervous system disorder: Most of the evidence from pathological conditions, including cardiovascular diseases, metabolic disorders, and neurological diseases, has demonstrated an increase in mitochondrial fission as indicated by increased expression of Drp1 and a decrease in mitochondrial fusion as indicated by the reduction of OPA1 and Mfn2 expression, causing an imbalance in the dynamics of the mitochondria [11,29], resulting in mitochondrial fragmentation [25].