The alterations in mitochondrial dynamics after cerebral ischemia/reperfusion in Sprague-Dawley rats were associated with the increase in cytochrome c release and caspase 3/7 activation in global cerebral ischemic neurons [25] and increased voltage-dependent anion channel-1 (VDAC1) expression in the hippocampus of Wistar rats in the following 3–72 h after reperfusion [35]. Here, VDAC1 is linked to brain ischemia.