ESR2 and breast neoplasm: Taking into account that patients with tumors with low ERα/ERβ ratios have a worse response to chemical agents oxidative damage inductors [56], we observed that breast tumors with a high correlation between IL6R and ESR2 in obese patients had genes related to mitochondrial biogenesis, and dynamics increased gene expression, which could be an attempt to increase the number of mitochondria due to the inflammatory state and oxidative stress generated over a long period of time, such happens in other situations like aging [57,58], but maintaining a functional mitochondrial pool.