BME treatment of Cal27 and JHU022 oral cancer cell lines downregulated the protein and mRNA expression levels of glycolytic genes phosphofructo kinase (platelet) (PFKB), pyruvate kinase muscle (PKM), pyruvate dehydrogenase kinase 3 (PDK3), glucose transporter-1 (SLC2A1/GLUT-1) and lactate dehydrogenase alpha (LDHA). This evidence concerns the gene PDK3 and lip and oral cavity carcinoma.