In addition to stimulatory effects on HO-1, many natural bioactive compounds, including epigallocatechin gallate, flavonoids, silymarin, flavonolignans, and various herbal supplements, exhibit inhibitory effects on UDP glucuronosyltransferase family 1 member A1 (UGT1A1) [85,110,111], thereby leading to hyperbilirubinemia. This evidence concerns the gene UGT1A1 and Hyperbilirubinemia.