Of the 60 genes involved in antioxidant activity (GO:0016209), TXNRD1 was the most frequently overexpressed gene across various cell lines: 15/31 cases of cancer cell lines showed upregulation of TXNRD1 (z-score > 1) by 100 μM necrostatin-1 (Figure 5). This evidence concerns the gene TXNRD1 and cancer.