To do so, in in vitro cellular models and in 3D tumor spheroids, we studied relevant MKIs in the presence of the superoxide dismutase (SOD) mimetic MnTBAP [24] and GSH modulators, such as the inhibitor of GSH synthesis (BSO) or the permeable GSH supplier (glutathione methyl ester, GSHe). This evidence concerns the gene SOD1 and neoplasm.