To see if for the OPSCC cases p16 expression, HPV-DNA-ISH, HPV-DNA-PCR, and p16-Ki67 dual stain are also independent predictors of patient survival, we performed multivariable analyses for factors associated with overall survival benefit using logistic regression models including patient age, UICC cancer stage, and smoking status (≥10 pack years vs. <10 pack years) as covariates. Here, CDKN2A is linked to cancer.