For HPV-DNA-PCR and p16-Ki67 dual staining, most positive cases were found in cancers of the oral cavity (HPV-DNA-PCR = 41% positive cases, 7/17; p16-Ki67 dual stain = 35%, 6/17) followed by the oropharynx (HPV-DNA-PCR = 37% positive cases, 29/78; p16-Ki67 dual stain = 31%, 24/78), hypopharynx (HPV-DNA-PCR = 17% positive cases, 4/23; p16-Ki67 dual stain = 22%, 5/23), and larynx (HPV-DNA-PCR = 17% positive cases, 6/35; p16-Ki67 dual stain = 17%, 6/35). Here, CDKN2A is linked to cancer.