KLK3 and cancer: In the first report of the complementary role of PHI and mpMRI in repeated biopsies [19], the authors found that the addition of PHI to mpMRI provided an improvement in the prediction of both overall cancers and csPCa with AUCs respectively of 0.71 and 0.75 compared to mpMRI (AUC 0.64) and PSA alone (AUC 0.69).