KLK3 and posterior cortical atrophy: All PSA-derived biomarkers, as well as PI-RADS score, were significantly associated with the risk of PCa at univariate analysis with an AUC ranging from 0.65 (95% CI: 0.559 to 0.742) for free PSA to 0.969 (95% CI: 0.948 to 0.990) in case of PHI (Table 2).