The development of HCC structure from dysplasia is a process influenced by proangiogenic factors such as angiopoietins, VEGF, transforming growth factors, basic fibroblast growth factors (bFGF), and platelet-derived growth factor (PDGF) that are secreted by TME and enhance tumor blood requirement from arteries to guarantee growth and metastatic spread. The gene discussed is FGF2; the disease is hepatocellular carcinoma.