RAD50 and esophageal squamous cell carcinoma: The prevalence of RAD50 LOF variants in Henan FH+ ESCC patients (4/372, 1.1%) was significantly more frequent compared to that from the East Asian population in the gnomAD public database (30/19,954, 0.15%) (OR = 7.22, p = 3.3 × 10−3).