Importantly, when we consider the RAD50 zinc hook domain localized to amino acid residues at 635–734 [28], three more zinc hook LOF pathogenic mutations (RAD50S653X [42], RAD50R656X [43], and RAD50E676X [44]) were reported in one NBS-like disorder and another six hereditary cancer predisposing syndrome patients from the ClinVar database. The gene discussed is RAD50; the disease is hereditary neoplastic syndrome.