ALDH3A2 and neoplasm: Van den Hoogen and co-workers suggested that ALDH3A2 does not contribute to the ALDH activity as detected by the ALDEFLUOR assay as no immunohistochemical staining was found in the primary tumor or normal prostate specimens, despite detecting high levels of ALDH3A2 mRNA in both the PCa cell lines and primary culture samples [37].