ALDH1A1 and Familial prostate cancer: In particular, a study by Jiang and co-authors demonstrated that silybin, a combination of flavonolignan and flavonoid polyphenolic compounds, inhibited cell growth, migration, and invasion of ALDH+ cells and downregulated ALDH1A1 expression in prostate cancer cell lines and xenograft tumors in the drug-treated mice [68].