The study suggested the cooperation of EZH2 and BRCA1 in regulating ALDH1A1 expression, PCa stem cells, and tumor radioresistance, and the genetic silencing of EZH2 alone or in combination with BRCA1 knockdown decreased the ALDH1A1 level [52,66]. This evidence concerns the gene ALDH1A1 and posterior cortical atrophy.