In PCa, seven ALDH genes (ALDH1A1, ALDH1A3, ALDH3A1, ALDH4A1, ALDH7A1, ALDH9A1, and ALDH18A1) are found elevated over healthy prostate tissues and potentially contribute to the ALDH activity measured by ALDEFLUOR assay. Here, ALDH18A1 is linked to posterior cortical atrophy.