LDHA and posterior cortical atrophy: This finding indicates that β-catenin and AR may cooperate in the transcriptional regulation of both ALDH isoforms in a cell line-dependent manner and that the transcription is shifted from ALDH1A1 to ALDH1A3 depending on the level of β-catenin or AR signaling activation, thereby reflecting the dynamic regulation of ALDHs during PCa progression [23].