ALDH3A2 and posterior cortical atrophy: In particular, Ferrari et al. demonstrated that ALDH3A2 was expressed higher in cells cultured in the presence of dihydrotestosterone together with antiandrogen bicalutamide as compared to androgen-independent cells cultured with bicalutamide alone, suggesting that ALDH3A2 might play a role in the development of the intermediate cellular phenotype during PCa progression to an androgen-refractory state [123].