A study by Nastały et al. comprising patient samples of primary PCa, hormone naїve lymph node (LN) metastases, castration-resistant visceral or bone metastases (n = 551) revealed that a high ALDH1A1 expression correlated with a higher T-stage and Gleason score, as well as a lower time to biochemical recurrence [21]. Here, ALDH1A1 is linked to posterior cortical atrophy.