Combining BRCA1 knockdown with the genetic silencing of methyltransferase EZH2 decreased or did not change ALDH1A3 gene expression in PCa cell lines but increased the ALDH+ populations in these cells, suggesting changes in other isoforms’ expression or posttranslational modifications leading to higher enzymatic activity [52]. The gene discussed is LDHA; the disease is posterior cortical atrophy.