In PCa, seven ALDH genes (ALDH1A1, ALDH1A3, ALDH3A1, ALDH4A1, ALDH7A1, ALDH9A1, and ALDH18A1) are found elevated over healthy prostate tissues and potentially contribute to the ALDH activity measured by ALDEFLUOR assay. This evidence concerns the gene ALDH4A1 and posterior cortical atrophy.