In an Affymetrix gene expression study performed on 24 androgen deprivation-resistant metastatic samples (of four patients) and primary PCa tissues, lower ALDH7A1 expression levels were found in the pooled metastatic samples from lymph nodes, lung, liver, and adrenal gland of each patient compared to the primary tissue expression [146]. The gene discussed is ALDH7A1; the disease is posterior cortical atrophy.