The MCP-1 protein, which is released by macrophages and regulatory T cells (Treg), regulates the expression of the endothelial growth inhibitor—tumor necrosis factor ligand superfamily member 15 (TNFSF15), causing a shift in the angiogenic balance in the tumor microenvironment toward inflammatory processes and neovascularization [66]. This evidence concerns the gene TNFSF15 and neoplasm.