Expression of IL-8 receptors in neoplastic cells, endothelial cells, neutrophils and macrophages shows that the autocrine and paracrine activities of IL-8 have a significant effect on tumor microenvironment by inducing multiple signal pathways contributing to angiogenesis, proliferation and migration of endothelial cells, survival and regulation of neutrophil infiltration into the microenvironment, which promotes metastatic activity [61]. The gene discussed is CXCL8; the disease is neoplasm.