TIMP1 and breast cancer: In turn, proapoptotic proteins such as Bax, Bim, Noxa, p21/Cip1 and PUMA, as well as DR4, DR5, tissue inhibitor of metalloproteinase-1 (TIMP1) and tissue inhibitor of metalloproteinase-2 (TIMP) were upregulated in BC cells after SAHA treatment.