In bivariate analyses, factors associated with poorer 24- and 36-month OS were G8 score ≤ 14, older age, restricted mobility, ≥1 abnormal ADL item, ≥1 abnormal IADL item, weight loss, a higher Gleason score, a higher serum PSA level, ECOG-PS, ≥1 CIRS-G grade 3 comorbidities or ≥1 CIRS-G grade 4 comorbidities, the risk of depression, cognitive impairment, and clinical stage (Table S4). The gene discussed is KLK3; the disease is major depressive disorder.