THOC1, THOC2, THOC5 and THOC6, members of the THO subcomplex of TREX [38] which participates in mRNA processing and transport of RNPs from nucleus to cytoplasm, are present in HMGB1 immunoprecipitates from ovary and prostate cancer cells. The gene discussed is THOC2; the disease is Familial prostate cancer.