The constitutive activation of NF-kB and JAK/STAT3 signaling is also frequently associated with the most aggressive nonGCB/ABC-DLBCL subtype [127], and a coordinated activity of both pathways has been demonstrated to be important in the metabolic reprogramming of DLBCL cells [128]. This evidence concerns the gene NFKB1 and diffuse large B-cell lymphoma.