Interestingly, this distinct PD-1hi phenotype in the RS lymphoma cells resembles that of protumorigenic PD-1hi Breg subsets recently identified in certain cancer types [76,77], for what it has been proposed that RS patients might specially benefit from therapy targeting PD-1/PD-L1 [179,182,183,184,185,186]. The gene discussed is CD274; the disease is cancer.