Yet, the exact role of IL-10 in B cell lymphomas remains controversial and urges further investigation, especially since IL-10 receptor (IL-10R) deficiency associates with lymphoma predisposition [139] and IL-10 may also possess anti-tumour functions by promoting CD8+ T cell responses in certain scenarios, including DLBCL [140,141,142]. This evidence concerns the gene CD8A and neoplasm.