Beyond this pro-survival effect, IL-10 production by the DLBCL cells could also promote immunosuppression by PD-L1 upregulation through intracellular mechanisms that involve JAK/STAT3 signaling [132], and mimic Breg-derived IL-10 secretion to suppress CD8 cytotoxic responses [61,73] (Figure 2, right). Here, CD274 is linked to diffuse large B-cell lymphoma.