It was found that Neurotrophic Tyrosine Kinase Receptor gene (NTRK1) was acetylated in both BPDCN cases and Cholinergic Receptor Nicotinic Beta 1 (CHRNB1) and GABA Type A Receptor-Associated Protein (GABARAP) genes in one case, leading to hypothesize a possible role of H3K27ac in neural signaling induction. Here, CHRNB1 is linked to CD4+/CD56+ hematodermic neoplasm.