EDN3 and neoplasm: Secondly, at the light of literature findings, among the network-genes related to neurogenesis (Figure 2B), the attention was focused on Neuroligin 4 X-linked (NLGN4X) and Endothelin-3 (EDN3), never reported before in BPDCN but already known to correlate with tumor aggressiveness [27,28,29].