Blocking the interleukin-6 (IL-6) crosstalk between CAFs and epithelial tumor cells negatively affects tumor growth in vitro as IL-6 might mediate the EMT in both subtypes, EAC and ESCC [60,61] via autocrine and paracrine secretion of this cytokine. The gene discussed is IL6; the disease is esophageal squamous cell carcinoma.