By stratification of newly diagnosed MM samples based on molecular clusters, we could confirm that the NFκB molecular cluster, which is defined by a high expression of genes involved in the NFκB pathway, also showed the highest STA NFκB pathway activity, with a median score of 44.0, compared to a combined median score of 35.2 in the other molecular clusters. This evidence concerns the gene NFKB1 and Miyoshi myopathy.