In general, a diagnosis of CD30+ PTCL, NOS with large cells should be made when the morphology and the immunoprofile of the tumor do not meet the features previously described for ALK- ALCL, namely, (1) a lack of sheets of large anaplastic cells, (2) a lack of “hallmark” cells, (3) a lack of a sinusoidal pattern, and (4) CD30 expression in <75% of lymphoma cells (Figure 6B). Here, TNFRSF8 is linked to mature T-cell and NK-cell non-Hodgkin lymphoma.