One study has shown that an immunohistochemical classifier using MDC/CCL22, CD83, STAT3, and TUBB2B has an accuracy of 97% to distinguish between CHL (all four markers positive) and ALK- ALCL (all four markers negative) [58], but these antibodies are not available in routine pathology practice. The gene discussed is STAT3; the disease is anaplastic large cell lymphoma.