JAK2 rearrangements have been recently identified in cases of CD30+/ALK- PTCL with an anaplastic morphology and eosinophilia that show CHL-like features and CD15 expression [91], suggesting that this abnormality might help to distinguish between PTCL with CHL-like features and ALK- ALCL with a “Hodgkin-like” pattern. This evidence concerns the gene JAK2 and classic Hodgkin lymphoma.