In 1985, H. Stein et al. recognized that a group of anaplastic hematopoietic tumors with particular nodal involvement were positive for Ki-1 (later designated CD30), HLA-DR, and frequently positive for ≥1 T-cell markers (few cases had a B-cell phenotype) and designated these neoplasms “ALCL” or “anaplastic Ki-1 large cell lymphoma” [6]. The gene discussed is TNFRSF8; the disease is hematopoietic and lymphoid cell neoplasm.