INS and pancreatic insulinoma: The transdifferentiated PANC-1 and MIA PaCa-2 cells expressed 80.63% and 56.1%, respectively, of the INS mRNA levels seen in the insulin-producing human insulinoma cell line NT-3 [39,40], while the abundance of SLC2A2 and MAFA transcripts was higher and lower, respectively, than in NT-3 cells (Figure S3B).