When PD-L1 CPS was categorized as three-tier with 1 and 50 as cut-off values, high TMB was significantly associated with high PD-L1 CPS in all cases (p = 0.005), gastric cancers (p = 0.001), and biliary tract cancers (p = 0.032; Table 2). Here, CD274 is linked to biliary tract neoplasm.