Jude Children’s Research Hospital analyzed the largest cohort of over one hundred cases of pediatric MPAL which identified genomic patterns that showed several recurrent alterations common in ALL (i.e., ETV6), AML (i.e., FLT3 and RUNX1), as well as those seen in both ALL/AML (i.e., WT1 and KMT2A) [12]. Here, RUNX1 is linked to acute myeloid leukemia.