FLT3 and acute lymphoblastic leukemia: These mutations include alterations in the JAK-STAT pathway in T/myeloid MPAL (seen in 57% versus 23% of B/myeloid) and ZNF384 rearrangements in B/myeloid, which leads to a higher FLT3 expression than typical B-ALL or T-lymphoid/myeloid MPAL [12].