Most studies investigating the mutational landscape of T/Myeloid MPAL are limited by small numbers but have reported mutations in ETV6, NOTCH1, WT-1, and FLT3, as well as in epigenetic modifiers or regulators, IKZF1 (Ikaros), and JAK/STAT signaling proteins [12,14,15,16,17]. Here, NOTCH1 is linked to mixed phenotype acute leukemia.