TF and neoplasm: As recently as this year, vascular TF was reported, for the first time, to contribute to trimethylamine N-oxide (TMAO) induced thrombosis, whereas co-expression of TF and podoplanin by glioblastoma cells was discovered to cooperatively impact tumor microthrombosis [3,4]; an emerging role of TF in COVID-19-associated coagulopathy is covered in the timely review by Mackman and colleagues [5].