Although we found that YAP knockdown upregulates the expression of the pro-apoptotic BH3 protein Bim, Bim remained sequestered to and inactivated by either Mcl1 or Bcl2, depending on the cell line tested—suggesting an alternative mechanism of cytotoxic therapy resistance by YAP occurs in neuroblastoma [51]. Here, BCL2 is linked to neuroblastoma.