Indeed, several studies reported that BRCA1 mRNA expression had predictive impact on responses to chemotherapy, as well as to chemoradiotherapy in many types of cancer, such as breast cancer, lung cancer, and esophageal cancer [27,28,29,30,31], suggesting BRCA1 as an attractive candidate for predicting nCRT response in LARC. Here, BRCA1 is linked to breast cancer.