So-called nano-engineered human MSCs, namely MSCs incorporated with drug-loaded nanoparticles (e.g., containing the anti-cancer drug paclitaxel or doxorubicin), or modified MSCs to improve their anti-tumor properties (e.g., following transduction to overexpress TNF-related apoptosis-inducting ligand (TRAIL), single interleukins, or interferons) were shown to reduce tumor growth by inducing apoptosis in tumor cells while sparing respective normal tissue cells [25,26,27,28]. This evidence concerns the gene TNFSF10 and neoplasm.