Accompanied gene expression profiling further identified a four-gene MSC signature comprising the genes GREM1 (Gremlin 1 DAN Family BMP Antagonist), LOXL2 (Lysyl Oxidase Like 2), ADAMTS12 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 12), and ITGA11 (Integrin Subunit Alpha 11) being induced in LR-MSCs following lung cancer education that functionally accounted for lung metastasis [45]. The gene discussed is LOXL2; the disease is lung cancer.