Nevertheless, when combining KRAS mutant mice with HuR overexpression compared with only KRAS mutant mice, they observed an increased incidence of PanIN lesions and up to 5-fold increased incidence of PDAs in the mice overexpressing HuR, supporting the notion that the inflammatory microenvironment induced by HuR expression in KRAS mutant mice promotes tumor formation [16]. This evidence concerns the gene KRAS and neoplasm.