CD274 and esophageal squamous cell carcinoma: The EMA, however, placed a restriction on the decision, as treatment with pembrolizumab was approved only for patients with a PD-L1 CPS of ≥10 (esophageal squamous cell carcinoma and PD-L1 CPS of ≥10: median OS 13.9 (n = 143) versus 8.8 (n = 143) months; HR 0.57; 95% CI 0.43–0.75; p < 0.0001; esophageal squamous cell carcinoma: 12.6 (n = 274) versus 9.8 (n = 274) months; HR 0.72; 95% CI 0.60–0.88; p = 0.0006; PD-L1 CPS ≥10: 13.5 (n = 186) versus 9.4 (n = 197) months; HR 0.62; 95% CI 0.49–0.78; p < 0.0001) [32,33].