Both niclosamide and pyrvinium effectively decreased TCF/LEF transcriptional activity (Figure 3C) and the expression of TCF/LEF target genes, including CD44, FGF18, ID2, EPHB2, EPHB3, MYCN, NOTUM, TCF4, and TCF7, in osteosarcoma cells at non-cytotoxic nM concentrations (Figure 3D). Here, NOTUM is linked to osteosarcoma.