CTLA4 and neoplasm: The importance of immune checkpoints, such as cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1), in modulating the anti-tumor T-cell response has been highlighted by the awarding of the 2018 Nobel Prize in Physiology or Medicine to James Allison and Tasuku Honjo.