CASP3 and cervical cancer: We found that 10 mM metformin and 20 μM everolimus monotherapy significantly downregulated antiapoptotic protein Bcl-2 and proliferation marker PCNA expressions, and upregulated proapoptotic protein Bax, cleaved-caspase-3, and cleaved-PARP-1 protein expression levels as compared with the control in cervical cancer CaSki and C33A cells.