Meanwhile, the growth of cervical cancer cells was found to be inhibited by a combination of metformin and nelfinavir; combining everolimus with paclitaxel treatment was observed to inhibit the PI3K/AKT/mTOR pathway expression, which is consistent with our study findings that everolimus combined with metformin therapy inhibited PI3K and p-AKT protein expressions in CaSki and C33A cells (Figure 6). This evidence concerns the gene AKT1 and cervical carcinoma.