Cold tumours are characterized by an immunosuppressive TME, rich in immunosuppressive cytokines, such as IL-10 and TGF-β and presence of M2-like macrophages and T-regulatory cells (Treg); hot tumours are rich in T CD8+ lymphocytes, which have been linked to the ability to respond to immunomodulatory therapies [172,173]. This evidence concerns the gene CD8A and neoplasm.