The iron transporter has been previously associated with an attenuation of macrophage-mediated immunity [213] and the glycoprotein NMB was found to be upregulated by TAM and induce cancer stem cell markers and tumour progression via binding to the CD44 in tumour cells, eliciting the expression of IL-33 and its receptor in different murine cancer models [214]. The gene discussed is CD44; the disease is cancer.