Although Bovy and collaborators did not isolate exosomes directly from the plasma of breast cancer patients in order to evaluate the role of this miRNA, these results may give insight into what would be happening in the tumor microenvironment in response to chemotherapy, since there are recent studies indicating, for example, that miR-503 can directly bind and inhibit BLACAT1 (bladder cancer-associated transcript 1), which is a long-non-coding RNA that has been found to promote chemotherapy resistance in T47D and MCF7 breast cancer cells [58]. This evidence concerns the gene BLACAT1 and neoplasm.