MCM8 and Premature ovarian insufficiency: So far, large-scale GWAS have identified several SNPs, such as rs11668344 (BRSK1), rs365132 (UIMC1) and rs16991615 (MCM8), relevant for age at natural menopause or premature ovarian insufficiency (POI) in the general population [12,60,61,62,63,64,65].