CHI3L1 and pancreatic neoplasm: Previous results from the Danish BIOPAC (BIOmarkers in patients with PAncreatic Cancer) study on 559–592 patients with pancreatic cancer found that plasma CRP, carbohydrate antigen 19-9 (CA 19-9), IL-6 and YKL-40 (see Supplementary Introduction) may each be independent biomarkers of overall survival [12,13].