Continuing to apply, also for oral cavity, the recommended guidelines regarding the detection of HPV in oropharyngeal squamous cell carcinomas (i.e., primary p16 IHC followed, only if positive, by PCR or in situ hybridization/ISH for HPV DNA), an unknown but perhaps higher number of OSCCs will very probably continue to be underdiagnosed, according to the related HPV status. Here, CDKN2A is linked to oropharynx squamous cell carcinoma.