KRAS and neoplasm: The components of CERR score include: KRAS/NRAS/BRAF-mutated tumor (1 point); node-positive primary (1 point); extrahepatic disease (1 point); CEA level > 200 ng/mL or carbohydrate antigen 19-9 (CA19-9) > 200 U/mL (1 point) and modified tumor burden score (calculated by the size, number and extension of LM) ranging between 5 and 11 (1 point) or 12 and over (2 points) [7].